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Global Melphalan Market Research Report 2024(Status and Outlook)

Global Melphalan Market Research Report 2024(Status and Outlook)

  • Category:Life Sciences
  • Published on : 21 October 2024
  • Pages :103
  • Formats:
  • Report Code:24MRES-8010059
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The "Global Melphalan Market" size was valued at US$ 187.3 Million in 2024 and is projected to reach US$ 234.6 Million by 2030, at a CAGR of 3.8% during the forecast period 2024-2030.

"United States Melphalan Market" size was valued at US$ 78.2 Million in 2024 and is projected to reach US$ 96.4 Million by 2030, at a CAGR of 3.5% during the forecast period 2024-2030.

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Melphalan is an alkylating chemotherapy agent used primarily in the treatment of multiple myeloma and certain types of cancers such as ovarian cancer. It works by interfering with DNA replication, thereby preventing cancer cells from growing and dividing. Here are key points about Melphalan:

  1. Mechanism of Action:

    • Melphalan is an alkylating agent that attaches alkyl groups to DNA, causing cross-linking and damage to the DNA strands. This disrupts the ability of cancer cells to replicate and divide, ultimately leading to cell death.
  2. FDA Approval:

    • Approved by the U.S. FDA for the treatment of multiple myeloma and ovarian cancer. It is also used as a conditioning regimen before bone marrow or stem cell transplants.
  3. Indications:

    • Primarily used in multiple myeloma and ovarian cancer. It is also employed in high doses for preparatory treatment before bone marrow or stem cell transplants in multiple myeloma patients.
  4. Administration:

    • Melphalan is available in both oral and intravenous forms. High-dose melphalan is typically administered intravenously, especially in preparation for stem cell transplants.
  5. Side Effects:

    • Common side effects include nausea, vomiting, hair loss, and suppression of bone marrow function leading to anemia, leukopenia, and thrombocytopenia. Long-term use increases the risk of secondary cancers, such as leukemia.
  6. Targeted Use:

    • While Melphalan is a non-targeted chemotherapy drug, it is specifically useful in cancers that are particularly sensitive to DNA damage, such as multiple myeloma.
  7. Bone Marrow Transplant Preparation:

    • High-dose Melphalan is commonly used as part of the conditioning regimen before autologous stem cell transplants to help destroy residual cancer cells and prepare the body for new healthy stem cells.
  8. Resistance:

    • Some cancer cells can develop resistance to Melphalan, often due to enhanced DNA repair mechanisms or changes in drug uptake by cancer cells.
  9. Clinical Trials:

    • Ongoing studies are exploring new formulations of Melphalan and its use in combination with other therapies to improve outcomes and reduce side effects in multiple myeloma and other cancers.
  10. Long-Term Risks:

    • There is a risk of developing secondary malignancies, such as leukemia or myelodysplastic syndromes, especially with long-term use or high doses.

Report Overview

This report provides a deep insight into the global Melphalan market covering all its essential aspects. This ranges from a macro overview of the market to micro details of the market size, competitive landscape, development trend, niche market, key market drivers and challenges, SWOT analysis, value chain analysis, etc.

The analysis helps the reader to shape the competition within the industries and strategies for the competitive environment to enhance the potential profit. Furthermore, it provides a simple framework for evaluating and accessing the position of the business organization. The report structure also focuses on the competitive landscape of the Global Melphalan Market, this report introduces in detail the market share, market performance, product situation, operation situation, etc. of the main players, which helps the readers in the industry to identify the main competitors and deeply understand the competition pattern of the market.

In a word, this report is a must-read for industry players, investors, researchers, consultants, business strategists, and all those who have any kind of stake or are planning to foray into the Melphalan market in any manner.

Global Melphalan Market: Market Segmentation Analysis
The research report includes specific segments by region (country), manufacturers, Type, and Application. Market segmentation creates subsets of a market based on product type, end-user or application, Geographic, and other factors. By understanding the market segments, the decision-maker can leverage this targeting in the product, sales, and marketing strategies. Market segments can power your product development cycles by informing how you create product offerings for different segments.

Key Company

  • GlaxoSmithKline
  • Celon Laboratories
  • Natco Pharma
  • Emcure Pharmaceuticals
  • GLS Pharma
By Type
  • 2mg Tables
  • 5mg Tables
  • 50mg Injections
By Application
  • Multiple Myeloma
  • Ovarian Cancer
  • AL Amyloidosis
  • Malignant Melanoma
  • Other
Geographic Segmentation
  • North America (USA, Canada, Mexico)
  • Europe (Germany, UK, France, Russia, Italy, Rest of Europe)
  • Asia-Pacific (China, Japan, South Korea, India, Southeast Asia, Rest of Asia-Pacific)
  • South America (Brazil, Argentina, Columbia, Rest of South America)
  • The Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Rest of MEA)
Key Benefits of This Market Research:
  • Industry drivers, restraints, and opportunities covered in the study
  • Neutral perspective on the market performance
  • Recent industry trends and developments
  • Competitive landscape & strategies of key players
  • Potential & niche segments and regions exhibiting promising growth covered
  • Historical, current, and projected market size, in terms of value
  • In-depth analysis of the Melphalan Market
  • Overview of the regional outlook of the Melphalan Market:
Key Reasons to Buy this Report:
  • Access to date statistics compiled by our researchers. These provide you with historical and forecast data, which is analyzed to tell you why your market is set to change
  • This enables you to anticipate market changes to remain ahead of your competitors
  • You will be able to copy data from the Excel spreadsheet straight into your marketing plans, business presentations, or other strategic documents
  • The concise analysis, clear graph, and table format will enable you to pinpoint the information you require quickly
  • Provision of market value (USD Billion) data for each segment and sub-segment
  • Indicates the region and segment that is expected to witness the fastest growth as well as to dominate the market
  • Analysis by geography highlighting the consumption of the product/service in the region as well as indicating the factors that are affecting the market within each region
  • Competitive landscape which incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions, and acquisitions in the past five years of companies profiled
  • Extensive company profiles comprising of company overview, company insights, product benchmarking, and SWOT analysis for the major market players
  • The current as well as the future market outlook of the industry concerning recent developments which involve growth opportunities and drivers as well as challenges and restraints of both emerging as well as developed regions
  • Includes in-depth analysis of the market from various perspectives through Porter

TABLE OF CONTENTS

Table of Contents
1 Research Methodology and Statistical Scope
1.1 Market Definition and Statistical Scope of Melphalan
1.2 Key Market Segments
1.2.1 Melphalan Segment by Type
1.2.2 Melphalan Segment by Application
1.3 Methodology & Sources of Information
1.3.1 Research Methodology
1.3.2 Research Process
1.3.3 Market Breakdown and Data Triangulation
1.3.4 Base Year
1.3.5 Report Assumptions & Caveats
2 Melphalan Market Overview
2.1 Global Market Overview
2.1.1 Global Melphalan Market Size (M USD) Estimates and Forecasts (2019-2030)
2.1.2 Global Melphalan Sales Estimates and Forecasts (2019-2030)
2.2 Market Segment Executive Summary
2.3 Global Market Size by Region
3 Melphalan Market Competitive Landscape
3.1 Global Melphalan Sales by Manufacturers (2019-2024)
3.2 Global Melphalan Revenue Market Share by Manufacturers (2019-2024)
3.3 Melphalan Market Share by Company Type (Tier 1, Tier 2, and Tier 3)
3.4 Global Melphalan Average Price by Manufacturers (2019-2024)
3.5 Manufacturers Melphalan Sales Sites, Area Served, Product Type
3.6 Melphalan Market Competitive Situation and Trends
3.6.1 Melphalan Market Concentration Rate
3.6.2 Global 5 and 10 Largest Melphalan Players Market Share by Revenue
3.6.3 Mergers & Acquisitions, Expansion
4 Melphalan Industry Chain Analysis
4.1 Melphalan Industry Chain Analysis
4.2 Market Overview of Key Raw Materials
4.3 Midstream Market Analysis
4.4 Downstream Customer Analysis
5 The Development and Dynamics of Melphalan Market
5.1 Key Development Trends
5.2 Driving Factors
5.3 Market Challenges
5.4 Market Restraints
5.5 Industry News
5.5.1 New Product Developments
5.5.2 Mergers & Acquisitions
5.5.3 Expansions
5.5.4 Collaboration/Supply Contracts
5.6 Industry Policies
6 Melphalan Market Segmentation by Type
6.1 Evaluation Matrix of Segment Market Development Potential (Type)
6.2 Global Melphalan Sales Market Share by Type (2019-2024)
6.3 Global Melphalan Market Size Market Share by Type (2019-2024)
6.4 Global Melphalan Price by Type (2019-2024)
7 Melphalan Market Segmentation by Application
7.1 Evaluation Matrix of Segment Market Development Potential (Application)
7.2 Global Melphalan Market Sales by Application (2019-2024)
7.3 Global Melphalan Market Size (M USD) by Application (2019-2024)
7.4 Global Melphalan Sales Growth Rate by Application (2019-2024)
8 Melphalan Market Segmentation by Region
8.1 Global Melphalan Sales by Region
8.1.1 Global Melphalan Sales by Region
8.1.2 Global Melphalan Sales Market Share by Region
8.2 North America
8.2.1 North America Melphalan Sales by Country
8.2.2 U.S.
8.2.3 Canada
8.2.4 Mexico
8.3 Europe
8.3.1 Europe Melphalan Sales by Country
8.3.2 Germany
8.3.3 France
8.3.4 U.K.
8.3.5 Italy
8.3.6 Russia
8.4 Asia Pacific
8.4.1 Asia Pacific Melphalan Sales by Region
8.4.2 China
8.4.3 Japan
8.4.4 South Korea
8.4.5 India
8.4.6 Southeast Asia
8.5 South America
8.5.1 South America Melphalan Sales by Country
8.5.2 Brazil
8.5.3 Argentina
8.5.4 Columbia
8.6 Middle East and Africa
8.6.1 Middle East and Africa Melphalan Sales by Region
8.6.2 Saudi Arabia
8.6.3 UAE
8.6.4 Egypt
8.6.5 Nigeria
8.6.6 South Africa
9 Key Companies Profile
9.1 GlaxoSmithKline
9.1.1 GlaxoSmithKline Melphalan Basic Information
9.1.2 GlaxoSmithKline Melphalan Product Overview
9.1.3 GlaxoSmithKline Melphalan Product Market Performance
9.1.4 GlaxoSmithKline Business Overview
9.1.5 GlaxoSmithKline Melphalan SWOT Analysis
9.1.6 GlaxoSmithKline Recent Developments
9.2 Celon Laboratories
9.2.1 Celon Laboratories Melphalan Basic Information
9.2.2 Celon Laboratories Melphalan Product Overview
9.2.3 Celon Laboratories Melphalan Product Market Performance
9.2.4 Celon Laboratories Business Overview
9.2.5 Celon Laboratories Melphalan SWOT Analysis
9.2.6 Celon Laboratories Recent Developments
9.3 Natco Pharma
9.3.1 Natco Pharma Melphalan Basic Information
9.3.2 Natco Pharma Melphalan Product Overview
9.3.3 Natco Pharma Melphalan Product Market Performance
9.3.4 Natco Pharma Melphalan SWOT Analysis
9.3.5 Natco Pharma Business Overview
9.3.6 Natco Pharma Recent Developments
9.4 Emcure Pharmaceuticals
9.4.1 Emcure Pharmaceuticals Melphalan Basic Information
9.4.2 Emcure Pharmaceuticals Melphalan Product Overview
9.4.3 Emcure Pharmaceuticals Melphalan Product Market Performance
9.4.4 Emcure Pharmaceuticals Business Overview
9.4.5 Emcure Pharmaceuticals Recent Developments
9.5 GLS Pharma
9.5.1 GLS Pharma Melphalan Basic Information
9.5.2 GLS Pharma Melphalan Product Overview
9.5.3 GLS Pharma Melphalan Product Market Performance
9.5.4 GLS Pharma Business Overview
9.5.5 GLS Pharma Recent Developments
10 Melphalan Market Forecast by Region
10.1 Global Melphalan Market Size Forecast
10.2 Global Melphalan Market Forecast by Region
10.2.1 North America Market Size Forecast by Country
10.2.2 Europe Melphalan Market Size Forecast by Country
10.2.3 Asia Pacific Melphalan Market Size Forecast by Region
10.2.4 South America Melphalan Market Size Forecast by Country
10.2.5 Middle East and Africa Forecasted Consumption of Melphalan by Country
11 Forecast Market by Type and by Application (2025-2030)
11.1 Global Melphalan Market Forecast by Type (2025-2030)
11.1.1 Global Forecasted Sales of Melphalan by Type (2025-2030)
11.1.2 Global Melphalan Market Size Forecast by Type (2025-2030)
11.1.3 Global Forecasted Price of Melphalan by Type (2025-2030)
11.2 Global Melphalan Market Forecast by Application (2025-2030)
11.2.1 Global Melphalan Sales (K Units) Forecast by Application
11.2.2 Global Melphalan Market Size (M USD) Forecast by Application (2025-2030)
12 Conclusion and Key Findings

LIST OF TABLES & FIGURES

List of Tables
Table 1. Introduction of the Type
Table 2. Introduction of the Application
Table 3. Market Size (M USD) Segment Executive Summary
Table 4. Melphalan Market Size Comparison by Region (M USD)
Table 5. Global Melphalan Sales (K Units) by Manufacturers (2019-2024)
Table 6. Global Melphalan Sales Market Share by Manufacturers (2019-2024)
Table 7. Global Melphalan Revenue (M USD) by Manufacturers (2019-2024)
Table 8. Global Melphalan Revenue Share by Manufacturers (2019-2024)
Table 9. Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in Melphalan as of 2022)
Table 10. Global Market Melphalan Average Price (USD/Unit) of Key Manufacturers (2019-2024)
Table 11. Manufacturers Melphalan Sales Sites and Area Served
Table 12. Manufacturers Melphalan Product Type
Table 13. Global Melphalan Manufacturers Market Concentration Ratio (CR5 and HHI)
Table 14. Mergers & Acquisitions, Expansion Plans
Table 15. Industry Chain Map of Melphalan
Table 16. Market Overview of Key Raw Materials
Table 17. Midstream Market Analysis
Table 18. Downstream Customer Analysis
Table 19. Key Development Trends
Table 20. Driving Factors
Table 21. Melphalan Market Challenges
Table 22. Global Melphalan Sales by Type (K Units)
Table 23. Global Melphalan Market Size by Type (M USD)
Table 24. Global Melphalan Sales (K Units) by Type (2019-2024)
Table 25. Global Melphalan Sales Market Share by Type (2019-2024)
Table 26. Global Melphalan Market Size (M USD) by Type (2019-2024)
Table 27. Global Melphalan Market Size Share by Type (2019-2024)
Table 28. Global Melphalan Price (USD/Unit) by Type (2019-2024)
Table 29. Global Melphalan Sales (K Units) by Application
Table 30. Global Melphalan Market Size by Application
Table 31. Global Melphalan Sales by Application (2019-2024) & (K Units)
Table 32. Global Melphalan Sales Market Share by Application (2019-2024)
Table 33. Global Melphalan Sales by Application (2019-2024) & (M USD)
Table 34. Global Melphalan Market Share by Application (2019-2024)
Table 35. Global Melphalan Sales Growth Rate by Application (2019-2024)
Table 36. Global Melphalan Sales by Region (2019-2024) & (K Units)
Table 37. Global Melphalan Sales Market Share by Region (2019-2024)
Table 38. North America Melphalan Sales by Country (2019-2024) & (K Units)
Table 39. Europe Melphalan Sales by Country (2019-2024) & (K Units)
Table 40. Asia Pacific Melphalan Sales by Region (2019-2024) & (K Units)
Table 41. South America Melphalan Sales by Country (2019-2024) & (K Units)
Table 42. Middle East and Africa Melphalan Sales by Region (2019-2024) & (K Units)
Table 43. GlaxoSmithKline Melphalan Basic Information
Table 44. GlaxoSmithKline Melphalan Product Overview
Table 45. GlaxoSmithKline Melphalan Sales (K Units), Revenue (M USD), Price (USD/Unit) and Gross Margin (2019-2024)
Table 46. GlaxoSmithKline Business Overview
Table 47. GlaxoSmithKline Melphalan SWOT Analysis
Table 48. GlaxoSmithKline Recent Developments
Table 49. Celon Laboratories Melphalan Basic Information
Table 50. Celon Laboratories Melphalan Product Overview
Table 51. Celon Laboratories Melphalan Sales (K Units), Revenue (M USD), Price (USD/Unit) and Gross Margin (2019-2024)
Table 52. Celon Laboratories Business Overview
Table 53. Celon Laboratories Melphalan SWOT Analysis
Table 54. Celon Laboratories Recent Developments
Table 55. Natco Pharma Melphalan Basic Information
Table 56. Natco Pharma Melphalan Product Overview
Table 57. Natco Pharma Melphalan Sales (K Units), Revenue (M USD), Price (USD/Unit) and Gross Margin (2019-2024)
Table 58. Natco Pharma Melphalan SWOT Analysis
Table 59. Natco Pharma Business Overview
Table 60. Natco Pharma Recent Developments
Table 61. Emcure Pharmaceuticals Melphalan Basic Information
Table 62. Emcure Pharmaceuticals Melphalan Product Overview
Table 63. Emcure Pharmaceuticals Melphalan Sales (K Units), Revenue (M USD), Price (USD/Unit) and Gross Margin (2019-2024)
Table 64. Emcure Pharmaceuticals Business Overview
Table 65. Emcure Pharmaceuticals Recent Developments
Table 66. GLS Pharma Melphalan Basic Information
Table 67. GLS Pharma Melphalan Product Overview
Table 68. GLS Pharma Melphalan Sales (K Units), Revenue (M USD), Price (USD/Unit) and Gross Margin (2019-2024)
Table 69. GLS Pharma Business Overview
Table 70. GLS Pharma Recent Developments
Table 71. Global Melphalan Sales Forecast by Region (2025-2030) & (K Units)
Table 72. Global Melphalan Market Size Forecast by Region (2025-2030) & (M USD)
Table 73. North America Melphalan Sales Forecast by Country (2025-2030) & (K Units)
Table 74. North America Melphalan Market Size Forecast by Country (2025-2030) & (M USD)
Table 75. Europe Melphalan Sales Forecast by Country (2025-2030) & (K Units)
Table 76. Europe Melphalan Market Size Forecast by Country (2025-2030) & (M USD)
Table 77. Asia Pacific Melphalan Sales Forecast by Region (2025-2030) & (K Units)
Table 78. Asia Pacific Melphalan Market Size Forecast by Region (2025-2030) & (M USD)
Table 79. South America Melphalan Sales Forecast by Country (2025-2030) & (K Units)
Table 80. South America Melphalan Market Size Forecast by Country (2025-2030) & (M USD)
Table 81. Middle East and Africa Melphalan Consumption Forecast by Country (2025-2030) & (Units)
Table 82. Middle East and Africa Melphalan Market Size Forecast by Country (2025-2030) & (M USD)
Table 83. Global Melphalan Sales Forecast by Type (2025-2030) & (K Units)
Table 84. Global Melphalan Market Size Forecast by Type (2025-2030) & (M USD)
Table 85. Global Melphalan Price Forecast by Type (2025-2030) & (USD/Unit)
Table 86. Global Melphalan Sales (K Units) Forecast by Application (2025-2030)
Table 87. Global Melphalan Market Size Forecast by Application (2025-2030) & (M USD)
List of Figures
Figure 1. Product Picture of Melphalan
Figure 2. Data Triangulation
Figure 3. Key Caveats
Figure 4. Global Melphalan Market Size (M USD), 2019-2030
Figure 5. Global Melphalan Market Size (M USD) (2019-2030)
Figure 6. Global Melphalan Sales (K Units) & (2019-2030)
Figure 7. Evaluation Matrix of Segment Market Development Potential (Type)
Figure 8. Evaluation Matrix of Segment Market Development Potential (Application)
Figure 9. Evaluation Matrix of Regional Market Development Potential
Figure 10. Melphalan Market Size by Country (M USD)
Figure 11. Melphalan Sales Share by Manufacturers in 2023
Figure 12. Global Melphalan Revenue Share by Manufacturers in 2023
Figure 13. Melphalan Market Share by Company Type (Tier 1, Tier 2 and Tier 3): 2023
Figure 14. Global Market Melphalan Average Price (USD/Unit) of Key Manufacturers in 2023
Figure 15. The Global 5 and 10 Largest Players: Market Share by Melphalan Revenue in 2023
Figure 16. Evaluation Matrix of Segment Market Development Potential (Type)
Figure 17. Global Melphalan Market Share by Type
Figure 18. Sales Market Share of Melphalan by Type (2019-2024)
Figure 19. Sales Market Share of Melphalan by Type in 2023
Figure 20. Market Size Share of Melphalan by Type (2019-2024)
Figure 21. Market Size Market Share of Melphalan by Type in 2023
Figure 22. Evaluation Matrix of Segment Market Development Potential (Application)
Figure 23. Global Melphalan Market Share by Application
Figure 24. Global Melphalan Sales Market Share by Application (2019-2024)
Figure 25. Global Melphalan Sales Market Share by Application in 2023
Figure 26. Global Melphalan Market Share by Application (2019-2024)
Figure 27. Global Melphalan Market Share by Application in 2023
Figure 28. Global Melphalan Sales Growth Rate by Application (2019-2024)
Figure 29. Global Melphalan Sales Market Share by Region (2019-2024)
Figure 30. North America Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 31. North America Melphalan Sales Market Share by Country in 2023
Figure 32. U.S. Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 33. Canada Melphalan Sales (K Units) and Growth Rate (2019-2024)
Figure 34. Mexico Melphalan Sales (Units) and Growth Rate (2019-2024)
Figure 35. Europe Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 36. Europe Melphalan Sales Market Share by Country in 2023
Figure 37. Germany Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 38. France Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 39. U.K. Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 40. Italy Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 41. Russia Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 42. Asia Pacific Melphalan Sales and Growth Rate (K Units)
Figure 43. Asia Pacific Melphalan Sales Market Share by Region in 2023
Figure 44. China Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 45. Japan Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 46. South Korea Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 47. India Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 48. Southeast Asia Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 49. South America Melphalan Sales and Growth Rate (K Units)
Figure 50. South America Melphalan Sales Market Share by Country in 2023
Figure 51. Brazil Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 52. Argentina Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 53. Columbia Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 54. Middle East and Africa Melphalan Sales and Growth Rate (K Units)
Figure 55. Middle East and Africa Melphalan Sales Market Share by Region in 2023
Figure 56. Saudi Arabia Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 57. UAE Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 58. Egypt Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 59. Nigeria Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 60. South Africa Melphalan Sales and Growth Rate (2019-2024) & (K Units)
Figure 61. Global Melphalan Sales Forecast by Volume (2019-2030) & (K Units)
Figure 62. Global Melphalan Market Size Forecast by Value (2019-2030) & (M USD)
Figure 63. Global Melphalan Sales Market Share Forecast by Type (2025-2030)
Figure 64. Global Melphalan Market Share Forecast by Type (2025-2030)
Figure 65. Global Melphalan Sales Forecast by Application (2025-2030)
Figure 66. Global Melphalan Market Share Forecast by Application (2025-2030)

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